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KMID : 0043319890120020094
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Archives of Pharmacal Research
1989 Volume.12 No. 2 p.94 ~ p.98
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Suppression of Diesel Emission Particle Extract-induced Micronuclei in Mouse Bone Marrow Cells by Pre-treatment with Ascorbic acid, alpha-Tocopherol or Glutathione
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Heo MY
Choi SK/Yu KS/Kim HP/Sohn DH
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Abstract
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Induction of micronuclei by diesel emission particle extract (DEPE) in mouse bone marrow cells was suppressed by pre-treatment with ascorbic acid, alpha-tocopherol or glutathione (GSH). These compounds were given orally to mice at the dose of 1, 10 or 100mg/kg/day for 5 consecutive days. The dose of DEPE (200mg/kg) was administered intraperitoneally once to mice with the 5th administration of test compounds. Ascorbic acid, alpha-tocopherol and GSH all showed the dose-dependent suppression on DEPE-induced micronuclei.
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